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Emerging Evidence: Magnesium and Vitamin D Supplementation Dampening Inflammation

Wednesday August 22, 2018
Emerging Evidence: Magnesium and Vitamin D Supplementation Dampening Inflammation

From arthritis to cardiovascular disease and diabetes, a magnitude of disorders that affect a large portion of the population stem from chronic inflammation in the body.


Detrimental if untreated, inflammatory disorders cause 3 in 5 deaths worldwide (1). Consuming a healthy, balanced diet and supplementing with magnesium and vitamin D may reduce inflammation, according to promising research (2,3).


In a meta-analysis of 20 trials conducted by Mousa et al in Australia, vitamin D supplementation significantly reduced markers of inflammation, namely C-reactive protein (CRP) in patients with type two diabetes (3). A total of 1,270 participants were included in the analysis, where doses administered ranged from 200 – 60,000 IU for a duration of 12 weeks to six months. 


Similarly, a meta-analysis of eight studies investigated by researchers in Iran, China and Poland observed positive effects of magnesium supplementation on CRP levels (2). Mazidi et al observed a -significant reduction in CRP levels following magnesium supplementation, which ranged between 320-1,500mg/day. Intervention duration ranged from one day to 6.5 months.


Mazidi et al suggested that when the body is depleted of magnesium, it triggers an inflammatory response that increases CRP and other inflammatory markers, eventually contributing to chronic inflammation. As the Western diet is low in magnesium, it may be beneficial to supplement with magnesium to replenish and prevent this detriment. On the other hand, vitamin D may produce anti-inflammatory effects due to its clear role in immune function and detoxification.


Although the pooled results from the meta-analysis are compelling, the researchers noted that long-term outcomes need to be further tested if the trials are replicated. Additionally, as the sample sizes were small in some of the included trials, it would be beneficial to test supplementation on larger groups to strengthen results.


As critical nutrients in the human diet, vitamin D and magnesium play integral roles in our health systems. In light of these new studies, supplementation may benefit those with chronic inflammation in order to potentially reduce disease risk and improve overall health.


After reviewing the analysis, Aimeé Benbow, Viridian Nutrition’s Technical Director, commented: “Both magnesium and vitamin D are generally regarded as safe for long-term use at 400mg for magnesium and 2,000IU vitamin D.”


Author: Salma Dawood is a Technical Advisor at Viridian Nutrition. She holds a BSc honours degree in Human Nutrition.

1)      R. Pahwa, I. Jialal, (2018) Chronic Inflammation, StatPearls Publishing
2)      Mazidi, M., Rezaie, P., & Banach, M. (2018). Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis. Archives of Medical Science : AMS, 14(4), 707–716.
3)      Aya Mousa, Negar Naderpoor, Helena Teede, Robert Scragg, Barbora de Courten; Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials, Nutrition Reviews, Volume 76, Issue 5, 1 May 2018, Pages 380–394,


The information contained in this article is not intended to treat, diagnose or replace the advice of a health practitioner. Please consult a qualified health practitioner if you have a pre-existing health condition or are currently taking medication. Food supplements should not be used as a substitute for a varied and balanced diet.


TAGS: Nutrition News and Viewsvitamin D, Magnesium


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